08 Mar
Lactobacillus increased IL 10
Posted by mike under enart.hubeidaxue.com
The present study determined the pattern of cytokine secretion (interleukin [IL]-1beta, tumor necrosis factor [TNF]-alpha, interferon [IFN]-gamma and IL-10). Lactobacillus plantarum 299v demonstrates beneficial immunomodulatory activity by increasing IL-10 synthesis and secretion in macrophages and T-cells derived from the inflamed colon. This may provide a mechanism through which probiotic bacteria ameliorate inappropriate inflammation and induce tolerance. (4)
Snowy: are you familiar with the relationship between Crohn's and Johnes? They're both micobacterium avian paratuberculosis. It's an "unmentionable" within the dairy industry. See this site (http://www.mad-cow.org/00/paraTB.html), among many. Regular pasteurization doesn't kill it - only the "ultra" temperatures will. Or have your own tested milk source.
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Don't some of the meds used to combat the flu, kill the bodies probiotic bacteria?
I hope we hear more about this. It would be a shame if the "vaccine" simply destroyed the one thing that could help.
R
It's usually antibiotics that kill the probiotics. Unless there is something about the anti-virals I don't know.
Unless the H5N1 virus caused a secondary bacterial pneumonia, I don't know why they'd use them. However, this is highly.
From all I know - the solution is KEEP THE VIRAL LOAD LOW.
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The innate immune system and commensal bacteria
The human large intestine (colon) contains an enormous (~1014) population of microorganisms. (Our bodies consist of only ~1013 cells!) Most of the species live there perfectly harmlessly; that is, they are commensals (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Symbiosis.html#Commensalism). Some are actually beneficial, e.g.,
by synthesizing vitamins (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/N/Nutrition.html#vitaminK)
by digesting polysaccharides for which we have no enzymes
by stimulating the development of the adaptive immune system, including Th1 helper cells (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Th1_Th2.html) (which then inhibit Th2 helper cells (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Th1_Th2.html#Reciprocal_inhibition_of_Th1_and_Th2_ cells.) which may provide protection against allergies like asthma) [Link (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Asthma.html#Innocuous)]Despite the name ("pathogen-associated"), PAMPs are found on all these nonpathogenic bacteria as well.
It turns out that not only do these bacteria not trigger inflammation, but their presence is needed (at least in mice) to maintain a healthy colon.
Mice that are raised in a germfree environment [Link (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Symbiosis.html#Commensalism)] or are treated with antibiotics to clean all the bacteria out of their colon are unhealthy and have G.I. tracts that are hypersensitive to injury. However, if they are given
LPS (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/I/Innate.html#Pathogen-Associated_Molecular_Patterns_(PAMPs)) (from livestock manure}(from gram-negative bacteria (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/Eubacteria.html#Classification_of_Eubacteria)) or
lipoteichoic acid (from the peptidoglycan (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Antibiotics.html#CellWall) of gram-positive bacteria (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/Eubacteria.html#Classification_of_Eubacteria))in their drinking water, their colons resist injury.
However, "knockout" mice that
lack TLR-2 or TLR-4 or
cannot signal through their TLRs [Link (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellSignaling.html#TNF-a)]are not protected by such treatment. These results
suggest that a continuous low level of activity of the innate immune system is essential to health — even in the absence of pathogens;
explain why deliberating feeding harmless bacteria ("probiotics") has proved beneficial to some human patients with a diseased colon;
provide another reason for avoiding the indiscriminate use of antibiotics (which kill harmless bacteria as easily as pathogenic ones).------------------------------------------------------------
My personal experience is that strategic use of probiotics can knock out some very nasty virus.....I'm a believer.
BTW - if you want some LPS exposure to trigger your immune system, I could use some help cleaning my goat barn!
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In the middle of the 80's I was animporter and a major distributor of Lacto Cultures.
Of course Idid someresearch then, Internet was not up, but here is what I have learned;
Acidophilus was mainly for the upper digestivese sytem and the small intestine, at high dose, wich is billions inthis cases, it was indeed efficient for Crohn diseases, intestine inflammation specifically localise in the small intestine. Then there is Bifidus, wich was efficient in the large intestine.
A good intestine flora indeed reduce inflammation, we hadthen 160 sales point and we where taking feeback on the ground and relayed this to a gastro-enterologist friend of mine, who was then convinced that Crohn disease was caused by a bacterias. I remember about a year an half ago a NEJM article corroborating his apprehension about the bacteria.
On the ground the effect of Bifidus was stated hundreds of times, specially from regions or cities that had problems withtheir water at the melting time at spring and at the canicules time end of July and August.
Then I went on to study the Kefir Cultures, part of the Causcasia diets, and find out that inflammation of the intestines was very seldom in regions where kefir was part of the diet. ( Many slovac cultures uses Kefir daily).
SO, active lacto-cultures have indeed good effects on Crohn patients, and it has reduced inflammation in hundreds of cases, this was from the ground feedback.
Don't some of the meds used to combat the flu, kill the bodies probiotic bacteria?
I hope we hear more about this. It would be a shame if the "vaccine" simply destroyed the one thing that could help.
R
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